Synthesis, Characterization and Antimicrobial studies of Co(II), Ni(II), Cu(II), Zn(II) and Fe(III) Complexes with Isatin Derivative

Metal complexes of Zn(II), Co(II), Ni(II), Cu(II) and Fe(III) with Schiff base derived from benzaldehyde and isatin monohydrazone have been synthesized & characterized on the basis of elemental analyses, IR spectral, electronic spectra. The elemental analyses of the complexes confine to the stoichiometry of the type ML2.2NO2 [M= Zn(II), Co(II), Ni(II), Cu(II)] and and [FeL2.2NO2] NO2. The redox properties of the complexes were extensively investigated by electrochemical method using cyclic voltammetry (CV). The Co(II) and Cu(II) complexes exhibited quasi-reversible single electron transfer process where as Zn(II) and Fe(III) complexes shown two redox peaks of quasi-reversible one electron transfer process. All the coloured complexes have been screened for their antimicrobial activity against fungi viz. A. niger, A. flavous, P. triticena, F. species & bacteria viz. E. coli, B. subtilis, S. typhi, S. aureus. The results of antimicrobial activity shows that metal complexes of bivalent metals have more potency towards experimental fungi & bacteria. It also shows that Cu(II) complex is more toxic against bacteria S. aureus.